|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> (+)-costunolide + flavin + 2 H2O
|
1.14.14.150
costunolide synthase
|
–
|
K
|
|
BRENDA:
BR49419
KEGG:
R09575
|
|
|
|
germacrene_A + 3 reduced_flavodoxin + 3 O2 <=> germacra-1(10),4,11(13)-trien-12-oate + 3 flavin + 4 H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
|
|
BRENDA:
BR49588
KEGG:
R12128
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.150
costunolide synthase
|
–
|
B
|
|
BRENDA:
BR52441
KEGG:
R12131
|
|
|
|
germacra-1(10),4,11(13)-trien-12-al + O2 + reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
B
|
|
BRENDA:
BR52446
KEGG:
R12130
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.168
germacrene A acid 8beta-hydroxylase
|
–
|
B
|
|
BRENDA:
BR52563
KEGG:
R12266
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 8-epi-inunolide + flavin + 2 H2O
|
1.14.14.170
8-epi-inunolide synthase
|
–
|
|
|
BRENDA:
BR52567
KEGG:
R12275
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_flavodoxin + O2 <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + flavin + H2O
|
1.14.14.170
8-epi-inunolide synthase
|
–
|
B
|
|
BRENDA:
BR52568
KEGG:
R12273
|
|
|
|
germacra-1(10),4,11(13)-trien-12-ol + 2 O2 + 2 reduced_flavodoxin <=> germacra-1(10),4,11(13)-trien-12-oate + 2 flavin + 3 H2O
|
1.14.14.95
germacrene A hydroxylase
|
–
|
K
|
|
BRENDA:
BS417032
KEGG:
R09548
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 6alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-15458
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 8beta-hydroxygermacra-1(10),4,11(13)-trien-12-oate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.168
germacrene A acid 8beta-hydroxylase
|
–
|
M
|
|
MetaCyc:
RXN-15460
|
|
|
|
germacrene_A + O2 + reduced_[NADPH-hemoprotein_reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + H2O + oxidized_[NADPH-hemoprotein_reductase] + H+
|
1.14.14.95
germacrene A hydroxylase
|
–
|
|
|
MetaCyc:
RXN-19749
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_[NADPH-hemoprotein_reductase] + O2 <=> 8alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oate + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-20049
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + reduced_[NADPH-hemoprotein_reductase] + O2 + H+ <=> 8-epi-inunolide + oxidized_[NADPH-hemoprotein_reductase] + H2O
|
1.14.14.170
8-epi-inunolide synthase
|
–
|
|
|
MetaCyc:
RXN-20051
|
|
|
|
germacra-1(10),4,11(13)-trien-12-al + O2 + reduced_[NADPH-hemoprotein_reductase] <=> germacra-1(10),4,11(13)-trien-12-oate + oxidized_[NADPH-hemoprotein_reductase] + H2O + H+
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-8970
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + O2 + reduced_[NADPH-hemoprotein_reductase] + H+ <=> (+)-costunolide + H2O + oxidized_[NADPH-hemoprotein_reductase]
|
1.14.14.150
costunolide synthase
|
–
|
|
|
MetaCyc:
RXN-8971
|
|
|
|
germacra-1(10),4,11(13)-trien-12-oate + NADPH + H+ + O2 <=> (+)-costunolide + NADP+ + 2 H2O
|
1.14.13.120
costunolide synthase
|
–
|
|
|
BRENDA:
BS442421
|
|